Description
Recipe:
Iron (II) Fumarate…………………………..200mg.
Folic acid………………………………………… .1000mcg.
Vitamin B12 (microcapsule form)………….50mcg.
Starch, Lactose, Avicel, Magnesium stearate.vp 1 capsule.
Specified:
All cases of anemia are due to lack of supply or loss of iron and hematopoietic factors.
Preventive treatment:
In cases of increased need for hematopoiesis such as in pregnant women, breastfeeding women, malnourished people, post-convalescence period, illness and children.
Evidence of iron, folic acid and vitamin B12 deficiency when the diet does not have enough of those elements.
Definition of contraindications:
Iron overload.
Pre-medication with cobalamin (Cyanocobalamin (spray) and similar substances). Melanoma.
Handling ADRs:
Occasional ADRs may be limited by taking low doses, followed by Increasing gradually or taking with a small amount of food.
Drug interactions:
Calcium (oral salt form) reduces the absorption of iron salts through the digestive tract. Iron salts should be taken away from meals and not taken with calcium.
Iron (injectable salt form) when combined with oral iron salts causes fainting and even shock due to the rapid release of iron from the complex form and cough: siderophyline.
Reduces the absorption of diphosphonates, cyclines, penicillamine through the digestive tract; reduces bioavailability of fluoroquinolones due to chelation; reduces the absorption of thyroxine through the digestive tract and reduces blood thyroxine. These medications should be taken more than 2 hours apart if possible.
Gastrointestinal bandages reduce the absorption of iron salts through the digestive tract.
Folic acid reduces plasma concentrations of enzyme-inducing anticonvulsants, enhancing the therapeutic effects as well as adverse effects of fluoro-uracile.
Handling ADRs:
Occasional ADRs may be limited by taking low doses, followed by Increasing gradually or taking with a small amount of food.
Drug interactions:
Calcium (oral salt form) reduces the absorption of iron salts through the digestive tract. Iron salts should be taken away from meals and not taken with calcium.
Iron (injectable salt form) when combined with oral iron salts causes fainting and even shock due to the rapid release of iron from the complex form and cough: siderophyline.
Reduces the absorption of diphosphonates, cyclines, penicillamine through the digestive tract; reduces bioavailability of fluoroquinolones due to chelation; reduces the absorption of thyroxine through the digestive tract and reduces blood thyroxine. These medications should be taken more than 2 hours apart if possible.
Gastrointestinal bandages reduce the absorption of iron salts through the digestive tract.
Folic acid reduces plasma concentrations of enzyme-inducing anticonvulsants, enhancing the therapeutic effects as well as adverse effects of fluoro-uracile.
Unwanted effects:
May cause digestive disorders, dark or black stools
Inform your doctor about unwanted effects when using the drug.
Use for pregnant and lactating women:
Good for pregnant and breastfeeding women.
Effects of the drug when driving or operating machinery:
Not yet recorded.
Overdose:
After taking too much medicine, cases of iron salt overdose have been recorded, especially in children under 2 years of age: symptoms include signs of gastrointestinal irritation and necrosis, in most cases there is accompanied by nausea, vomiting and shock.
Treat as soon as possible by washing the stomach with 1% sodium bicarbonate solution.
Using a chelating agent that is also most effective is deferoxamine, especially when the plasma iron concentration exceeds 5mcg/ml. Shock, dehydration, and acid-base abnormalities are treated in the usual manner.
Dynamic characteristics:
Fezidate tablets provide iron, folic acid, and hematopoietic factors:
Fezidate capsules contain iron (II) fumarate, a form with a high iron content (33%). Each tablet provides the body with about 66mg of elemental iron, which is an important element involved in the structure of hemoglobin, myoglobin and the respiratory enzyme cytochrome C.
Vitamin B12 plays an important role in preventing and treating anemia by increasing red blood cell growth. In addition, vitamin B12 also plays a very important role in the process of dividing and regenerating tissue cells.
Folic acid is a B vitamin. In the body, it is reduced to tetrahydrofolate, which is a coenzyme of many metabolic processes, including the synthesis of purine or pyrimidine nucleotides; thus affecting DNA synthesis. In the presence of vitamin C, folic acid is converted to leucovorin, which is necessary for the synthesis of DNA and RNA. Folic acid is an indispensable factor for nucleoprotein synthesis and normal erythropoiesis; Folic acid deficiency causes megaloblastic anemia similar to anemia caused by vitamin B12 deficiency. The combination of vitamin B12 with folic acid creates optimal effects in cell growth and reproduction, especially red blood cell formation. In addition, folic acid also participates in some amino acid changes, in the formation and use of formate.
Pharmacokinetic properties:
Vitamin B12:
After oral administration, vitamin B12 is absorbed through the intestines, mainly in the ileum, by two mechanisms: passive mechanism when consumed in large amounts; and the active mechanism, which allows absorption of physiological doses, but requires the intrinsic factor glycoprotein secreted by the gastric mucosal cells. The extent of absorption is about 1% independent of dose and therefore 1 mg daily will satisfy the daily requirement and be sufficient to treat all forms of vitamin B12 deficiency. After absorption, vitamin B12 binds with transcobalamin II and is rapidly removed from the plasma for preferential distribution into the liver parenchyma. The liver is where vitamin B12 is stored for other tissues. About 3mcg of cobalamin is excreted into bile every day, of which 50 – 60% are cobalamin derivatives that cannot be reabsorbed.
Folic acid:
Released rapidly in the stomach and absorbed mainly in the first part of the small intestine. Folic acid in a normal diet is absorbed very quickly and distributed in tissues in the body. The drug is stored mainly in the liver and is actively concentrated in the cerebrospinal fluid. Every day about 4 – 5mcg is excreted through urine. Taking high doses of folic acid causes the amount of vitamin excreted in urine to increase proportionally. Folic acid crosses the placenta and is present in breast milk.
Iron:
Absorption: Iron (II) is easily absorbed through the lining of the stomach and intestines. In the intestine, Iron (II) is attached to an albumin in the intestinal mucosa cells, apoferritin, to form ferritin, which enters the blood.
Distribution: In the blood ferritin releases iron and the iron is attached to a glycoprotein, a specific iron transporter called transferrin. Through transferrin, iron is transferred to tissues such as bone marrow, partly in reserve form in the liver, spleen, and bone marrow, and partly to create red blood cells and enzymes.
Metabolism: participates in many metabolic processes in the body.
Elimination: mainly through feces (90%), a small part through sweat, urine, and menstruation.
SHELF LIFE: 24 months from date of manufacture.
Do not exceed the time limit stated on the packaging.
STORAGE: Dry, cool place, temperature below 300C. Avoid light.
STANDARD: TCCS.
