Description

Recipe:

Thiamin nitrate…………………………………………: 125mg.
Pyridoxine hydrochloride……………………………..: 125mg.
Cyanocobalamin (Vitamin B12) ……………………..: 50mcg.
Wheat starch, Avicel, Magnesium stearate, HPMC, Titanium dioxide,
Ponceau 4R lake ..vs one film-coated tablet.

Point:
Prevention and treatment of deficiency of B vitamins due to nutritional causes.
Detoxification treatment for alcoholism.
High doses are used in some rheumatic or neuropathic pain syndromes.

Contraindications:
History of sensitivity to cobalamin.
Hypersensitivity to any component of the medication.

Unwanted effects:
Allergic reactions are very rare.
Using high and prolonged doses of vitamin B6 can cause peripheral nerve manifestations, such as paresthesias.
Inform your doctor of any unwanted effects you encounter when using the drug.

How to use:
1-2 tablets/day.

Drug interactions:
Related to VitaminB6.
Pyridoxine reduces the effectiveness of levodopa in the treatment of Parkinson’s disease, this does not happen with the mixture levodopa – carbidopa or levodopa – benserazid.
Vitamin B6 dose of 200mg/day can cause a 40 – 50% reduction in phenytoin and phenobarbiton levels in the blood of some patients.
Pyridoxine may alleviate depression in women taking birth control pills.
Birth control pills may increase the need for pyridoxine.

Careful :
High and prolonged doses of vitamin B6 should not be used. Use at a dose of 200mg/day and for prolonged periods can cause severe peripheral neuropathy and sensory neuropathy, in addition to causing vitamin B6 dependence.

Use for pregnant and lactating women:
Pregnancy: related to vitamin B6: if used in supplement doses according to daily needs, it does not harm the fetus, but at high doses it can cause drug dependence syndrome in newborns.
Breastfeeding period: no effect when used as daily needs.

Overdose and treatment:
Not yet recorded.
In case of drug overdose, the patient should be taken to the nearest medical facility for timely treatment.

Pharmacodynamic properties:
Franvit 3B combines 3 B vitamins including B1, B6, B12.
Vitamin B1 plays an important role in generating energy necessary for cellular needs (Krebs cycle, 5C sugar metabolism and acetylcholine synthesis).
Vitamin B6 is a coenzyme of about 10 different enzymatic reactions, participating in the formation of serotonin, vitamin PP, and in the synthesis of GABA.
Vitamin B12, as a coenzyme, plays a key role in hematopoiesis.

Pharmacokinetic properties:
Thiamin is absorbed in the upper part of the duodenum, then transferred to the liver by the portal vein. Thiamine is found in all tissues in low concentrations. After serving as a carboxylase, thiamin is degraded and its metabolites are excreted by the kidneys. In high amounts, thiamine can be found unchanged in urine and sweat.
Vitamin B6 is rapidly absorbed and participates in many metabolic reactions in the form of pyridoxal. This substance is excreted mainly through urine.
Vitamin B12 is absorbed in the intestine by two mechanisms: a passive mechanism when present in high amounts and an active mechanism allowing absorption at physiological doses, in which case the presence of an intrinsic factor is required . Vitamin B12 is essential in the progression of many enzymatic reactions, mainly for lipids, proteins and nucleic acids. In case of excess vitamin B12, excretion is mainly through urine.

SHELF LIFE: 36 months from date of manufacture.
Do not exceed the time limit stated on the packaging.
STORAGE: Dry, cool place, temperature not exceeding 300C. Avoid light.
STANDARDS: TCCS